Samuel T. Hess

Samuel T. Hess Sam-Hess_1846
Professor of Physics

  • B.S., Physics, Yale University, 1995
  • M.S., Physics, Cornell University, 1998
  • Ph.D., Physics, Cornell University, 2002

Office: 313 Bennett Hall

Phone: (207)581-1036


Other Webpages:

Research Interests:

  • Experimental and Theoretical Biophysics,
  • Fluorescence Microscopy and Spectroscopy,
  • Function and Lateral Organization of Biomembranes,
  • Single Molecule Fluorescence Photophysics,
  • Green Fluorescent Proteins.

Recent Presentations:

Recent publications:

“Spectral Fluorescence Photoactivation Localization Microscopy,” Michael Mlodzianoski, M. S. Gunewardene, and Samuel T. Hess, PLoS One 11(3): e0147506 (2016).

“Clean Localization Super-resolution Microscopy for 3D Biological Imaging,” Partha P. Mondal, Nikki M. Curthoys, and Samuel T. Hess, AIP Advances 6, 015017 (2016).

“Super Resolution Fluorescence Localization Microscopy,” Michael J. Mlodzianoski, Matthew M. Valles, Samuel T. Hess, in Encyclopedia of Cell Biology, Ed. Ralph Bradshaw, Philip Stahl and John Heuser & Sergio Grinstein (2016).

“Antimicrobial Agent Triclosan is a Proton Ionophore Uncoupler of Mitochondria in Living Rat and Human Mast Cells and in Primary Human Keratinocytes,” Lisa M. Weatherly, Juyoung Shim, Hina N. Hashmi, Rachel H. Kennedy, Samuel T. Hess, and Julie A. Gosse, Journal of Applied Toxicology Jul 23. doi: 10.1002/jat.3209 (2015).

“Dances with Membranes: Breakthroughs from Super-Resolution Imaging,” Nikki M. Curthoys, Matthew Parent, Michael Mlodzianoski, Andrew J. Nelson, Jennifer Lilieholm, Michael B. Butler, Matthew Valles, and Samuel T. Hess, in Current Topics in Membranes, Ed. Anne Kenworthy (2015).

“Nanoscale Imaging of Caveolin-1 Membrane Domains in vivo,” Kristin A. Gabor, Dahan Kim, Carol H. Kim, and Samuel T. Hess, PLoS One 10(2): e0117225 (2015).

“Combining Total Internal Reflection Sum Frequency Spectroscopy Spectral Imaging and Confocal Fluorescence Microscopy,” Edward S. Allgeyer, Sarah M. Sterling, Mudalige S. Gunewardene, Samuel T. Hess, David J. Neivandt, and Michael D. Mason, Langmuir 31 (3): 987-994 (2015).

“Precisely and accurately localizing single emitters in fluorescence microscopy: state-of-the-art and best practice,” Hendrik Deschout, Francesca Cella Zanacchi, Michael Mlodzianoski*, Alberto Diaspro, Joerg Bewersdorf, Samuel T. Hess, and Kevin Braeckmans, Nature Methods, accepted.

“Visualizing the Molecular Timing of a Physiological Decision at the Nanoscale,” Samuel T. Hess and Julie A. Gosse, Biophysical Journal 105:2617-8 (2013).

“Simultaneous Multicolor Imaging of Biological Structures with Fluorescence Photoactivation Localization Microscopy,” N.M. Curthoys*, M.J. Mlodzianoski*, D. Kim*, and S.T. Hess, Journal of Visualized Experiments (82), e50680 (2013).

“Bleed-through correction for rendering and correlation analysis in multi-colour localization microscopy, “ Dahan Kim,* Nikki M. Curthoys,* Matthew T. Parent,* and Samuel T. Hess, Journal of Optics 15: 094011 (2013).

“Super Resolution Microscopy Reveals that Caveolin-1 is required for antiviral immune response,” Kristin A Gabor,* Chad R Stevens, Matthew J Pietraszewski, Travis J Gould,* Siew Hong Lam, Zhiyuan Gong, Samuel T Hess, Carol H Kim, PLoS One 8: e68759 (2013).

“Actin Mediates the Nanoscale Membrane Organization of the Clustered Membrane Protein Influenza Hemagglutinin” Manasa V. Gudheti*, Nikki M. Curthoys*, Travis J. Gould*, Dahan Kim*, Kristin A. Gabor*, Mudalige S. Gunewardene*, Joshua Zimmerberg, Julie A. Gosse, Carol H. Kim, and Samuel T. Hess, Biophysical Journal, 104: 2182-92 (2013).